The software package OMA & OPA was created to support the interpretation of oligonucleotide mass spectra. It can rapidly calculate all theoretically possible fragment ions for a given input sequence and annotate them to an experimental spectrum, thus, saving a large amount of manual processing time. The software includes analysis of precursor and product ion spectra of unmodified and modified oligonucleotides, and their adducts with metal ions and chemotherapeutic drugs. Oligonucleotide structures may incorporate single or multiple sugar-, backbone-, or nucleobase-modifications. A selection of common structural modifications has already been integrated in the software, but the user can add any modified building block or adduct to the library. These features turn the OMA & OPA software to a versatile and accurate tool for the interpretation of product ion spectra of highly modified nucleic acids.
How to cite
To cite any application in relation to the software or the original publication, please cite:
OMA and OPA - Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. A. Nyakas, L.C. Blum, S.R. Stucki, J.-L. Reymond, S. Schürch J. Am. Soc. Mass Spectrom.2012, 23, XXX-XXX.
Terms & Conditions
This program was developed in the hope that it will be useful. However, the software is provided "as-is", without warranty of any kind. It was developed for research purposes only and in no event the authors shall be held liable for any damages or other consequences arising from the use of the software.
You may download and use the software free of charge, but you are not allowed to modify or to redistribute it without the written permission of the authors. All data provided by the user for download will be treated confidential.